“Further controlled prospective studies may provide more evidence about the prognostic and diagnostic utility of MPV in larger SLE populations,” they concluded. They noted that the sample size was small and the study was retrospective.
However, more studies are needed on this issue, the authors wrote. Larger platelets are activated more easily than smaller ones by adenosine diphosphate, collagen, and epinephrine, releasing greater amounts of thromboxane A2, platelet factor 4 and thromboglobulin. High blood platelet counts can be caused by several conditions, including anemia, cancer, inflammation and infection. “We consider that MPV may be a new activation indicator for SLE,” they said.Ī possible explanation for the increase in MPV may be activity of autoantibodies, thrombocyte activation, and the release of vasoactive and thrombogenic molecules, which occur in SLE disease. Using the cut-off value of 7.8 fL, MPV had maximum sensitivity and specificity, indicating that the probability of SLE increases remarkably at that level. At a value of 7.8 fL for MPV, the sensitivity and specificity were 69% and 42%, respectively ( P <.001 95%CI, 0.69-0.89). The receiver operator characteristic (ROC) curve had an area under the curve of 0.79. The analysis also tested for specificity and sensitivity of MPV. High MPV values were independent of age, body mass index, ESR, and CRP, according to a multiple regression analysis. The researchers found a statistically significant positive link between MPV with arthritis, nephritis, central nervous system involvement, vasculitis, and SLEDAI. CRP levels were also higher patients compared with controls (8.2 versus 4.5. In the patient group, ESR level was 30.7 and 16.7. The mean age of the patients with SLE was 37 and in the control group it was 33.7. Clinical findings and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) were also evaluated. Measurements included erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP) levels, and MPV levels. Their case-control, retrospective study included 39 female patients with SLE and 45 controls. In a literature search, the authors found a few studies about MPV values with inflammatory markers in juvenile and adult patients with SLE. Several studies have shown that MPV may be a sign of inflammation in some chronic diseases, so the intent of the study, published in the International Journal of Clinical Practice, was to determine whether there is a connection between MPV with SLE and inflammatory markers. There is no single biomarker for SLE, the researchers noted, and so they wanted to investigate whether there is a connection between MPV and the disease. doi:10.In a recent study, researchers described findings that illustrate how mean platelet volume (MPV) may serve as a biomarker of systemic lupus erythematosus (SLE). Stress enhances proinflammatory platelet activity: the impact of acute and chronic mental stress. Koudouovoh-Tripp P, Hüfner K, Egeter J, et al. Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data. Platelet gene expression and function in patients with COVID-19. Manne BK, Denorme F, Middleton EA, et al. A low platelet count is called thrombocytopenia 2. This may sound like a lot, but since they are tiny, they take up a very small part of total blood volume. Etiology of thrombocytosis in a general medicine population: analysis of 801 cases with emphasis on infectious causes. MPV Results According to the National Library of Medicine, a normal platelet count is 150,000 to 400,000 per microliter of blood 2. Rose SR, Petersen NJ, Gardner TJ, Hamill RJ, Trautner BW. Cancer incidence following a high-normal platelet count: cohort study using electronic healthcare records from English primary care. Use of multiple inflammatory marker tests in primary care: using clinical practice research datalink to evaluate accuracy. They include weakness, bleeding, headache, dizziness, chest pain. Watson J, Jones HE, Banks J, Whiting P, Salisbury C, Hamilton W. The signs and symptoms of a high platelet count are linked to blood clots and bleeding. Kucine N, Chastain KM, Mahler MB, Bussel JB. Pathophysiology, classification, and complications of common asymptomatic thrombocytosis in newborn infants. National Heart, Blood, and Lung Institute. National Heart, Lung, and Blood Institute.
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